Coagulation Testing

If a test you are looking for is not listed we would be happy to investigate specific requirements and potential validations as required.

 

Screening Tests

  1. Prothrombin Time (PT)
  2. activated Partial Thromboplastin Time (aPTT)
  3. Thrombin Clotting Time (TCT)
  4. Kaolin Clotting Time (KCT)

 

Assessment of the Fibrinolytic Pathway

  1. Alpha-2-antiplasmin – functional assay
  2. Euglobulin Lysis Time
  3. Fibrinogen/fibrin degradation products (FDP)
  4. Plasmin alpha-2-antiplasmin complex (PAP)
  5. Plasminogen Activator Inhibitor – antigen (PAI-1)
  6. Plasminogen Activator Inhibitor – functional (PAI-1)
  7. Plasminogen – antigen
  8. Plasminogen – functional assay
  9. Thrombin Activatable Fibrinolytic Inhibitor (TAFI)
  10. Tissue Plasminogen Activator (t-PA) – total antigen
  11. Tissue Plasminogen Activator (t-PA) – functional assay

 

Thrombosis Screening Tests:

  1. Activated Protein C Resistance assay (APCR)
  2. Anti-thrombin – antigen
  3. Anti-thrombin – functional assay
  4. Factor XI antigen
  5. Heparin Cofactor II – functional (chromogenic)
  6. Heparin Cofactor II – antigen
  7. Heparin-induced antibody assay (HIT):
    • PF4 Binding assay
    • Serotonin Release assay
  8. Homocysteine
  9. Lipoprotein (a)
  10. Protein C – antigen
  11. Protein C – functional assay (Clotting)
  12. Protein C – functional assay (chromogenic)
  13. Protein S – antigen (total and/or free antigen)
  14. Protein S – functional assay (Clotting)
  15. Reptilase
  16. Tissue Factor Pathway Inhibitor (TFPI)

 

Markers of Thrombin Generation:

  1. Thrombin-antithrombin Complex (TAT)
  2. Prothrombin fragment 1.2 (F1.2)
  3. Activated Factor VII (VIIa)
  4. D-Dimer (Quantitative and Semi-Quantitative)
  5. Soluble Fibrin Monomer
  6. Human Tissue Factor Ag
  7. Endogenous thrombin potential

 

Markers of Platelet Activation:

  1. Beta-Thromboglobulin (BTG)
  2. Platelet Factor 4 (PF4)
  3. P-Selectin

 

Measurement of thromboxane B2 suppression (Aspirin resistance)

  1. 11-dehydro Thromboxane B2 (Urine)
  2. Serum Thromboxane B2 assay.


Markers of Endothelial Activation:

  1. sE-Selectin
  2. Endothelin 1

 

Monitoring Anticoagulant Therapy:

  1. Heparin anti-IIa assay
  2. Heparin anti-Xa assay (LMWH, UFH, Fondaparinux)
  3. Hirudin assay
  4. Ecarin Clotting Time
  5. Anti-Xa Heparin Assays for establishing an aPTT therapeutic range for Unfractionated Heparin (UFH).

 

 

Antiphospholipid Antibody Evaluation:

  1. Anticardiolipin assay – specific measurement – IgG – IgM – IgA
  2. Anti-phosphotidylserine
  3. Anti-beta-2-glycoprotein
  4. Clotting assays for Lupus Anticoagulant:
    - Dilute Russell viper venom time (DRVV)
    - Lupus sensitive aPTT
    - Dilute prothrombin time
    - Kaolin Clotting time
  5. Confirmation Tests:
    - Hexagonal phospholipid
    - RVV Confirmation

 

Coagulation Protein Analysis:

  1. Coagulant Assays – Factor II to XII Functional
  2. Coagulant Assays – Factor II to XII Antigen
  3. Factor VIII (Chromogenic)
  4. Factor Inhibitor (FII to XII)
  5. Factor VIII Inhibitor assay (Bethesda)
  6. Factor XIII Assay – Quantitative (Chromogenic)
  7. Fibrinogen – Clauss functional Assay
  8. Fibrinogen antigen
  9. Prekallikrein Assay (Chromogenic)
  10. von Willebrand Factor antigen assay (vWF:ag)
  11. von Willebrand Ristocetin CoFactor
  12. Tissue Factor Acitivty

 

DNA Analysis:

  1. Factor V Leiden R506Q mutation
  2. 2.Prothrombin 20210 AG genotype
  3. Methyl Tetrahydrofolate Reductase (MTHFR) Mutation
  4. Cytochrome P 450 CYP2C9 *2 & CYP2C9 *3
  5. VKORC1 (vitamin K epoxide reductase complex, subunit 1)

 

Miscellaneous:

  1. Adiponectin
  2. Procalcitonin

 

Cytokines

  1. IL-1 beta
  2. IL-1 beta High Sensitivity
  3. sIL-2R
  4. IL-6
  5. IL-1ra
  6. IFN-gamma
  7. MMP-3
  8. MMP-9
  9. s-ICAM-1
  10. s-VCAM-1
  11. TNF-alpha
  12. TNF-alpha High Sensitivity
  13. TGF-alpha
  14. TGF-beta
  15. TNF sTNF R1
  16. TNF sTNF R2